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Target3-oxoacyl-[acyl-carrier-protein] synthase 1
LigandBDBM50138281
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330089
IC50 20000±n/a nM
Citation Kim PZhang YMShenoy GNguyen QABoshoff HIManjunatha UHGoodwin MBLonsdale JPrice ACMiller DJDuncan KWhite SWRock COBarry CEDowd CS Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem 49:159-71 (2006) [PubMed]  Article
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3-oxoacyl-[acyl-carrier-protein] synthase 1
Name:3-oxoacyl-[acyl-carrier-protein] synthase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:42605.82
Organism:Escherichia coli (strain K12)
Description:ChEMBL_330089
Residue:406
Sequence:
MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI
DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM
RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG
KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV
EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT
STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN
IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD
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  Blast E-value cutoff:
BDBM50138281
n/a
NameBDBM50138281
Synonyms:4-Hydroxy-3,5-dimethyl-5-((E)-2-methyl-buta-1,3-dienyl)-5H-thiophen-2-one | 4-Hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5H-thiophen-2-one(Thiolactomycin) | CHEMBL322740 | rac-thiolactomycin
TypeSmall organic molecule
Emp. Form.C11H14O2S
Mol. Mass.210.293
SMILESCC1C(=O)SC(C)(\C=C(/C)C=C)C1=O
Structure
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