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Target3-oxoacyl-[acyl-carrier-protein] synthase 3
LigandBDBM50134355
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330090 (CHEMBL863388)
IC50>1000000±n/a nM
Citation Kim, PZhang, YMShenoy, GNguyen, QABoshoff, HIManjunatha, UHGoodwin, MBLonsdale, JPrice, ACMiller, DJDuncan, KWhite, SWRock, COBarry, CEDowd, CS Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem49:159-71 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-oxoacyl-[acyl-carrier-protein] synthase 3
Name:3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:Enzyme
Mol. Mass.:33506.68
Organism:Escherichia coli
Description:C3TDZ2
Residue:317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAAT
RAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALS
VADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLH
ADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDW
LVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVL
LEAFGGGFTWGSALVRF
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  Blast E-value cutoff:
BDBM50134355
n/a
NameBDBM50134355
Synonyms:5-(4-tert-Butyl-benzyl)-4-hydroxy-3,5-dimethyl-5H-thiophen-2-one | 5-(4-tert-butylbenzyl)-3,5-dimethyl-4-hydroxy-5H-thiophen-2-one | CHEMBL333571
TypeSmall organic molecule
Emp. Form.C17H22O2S
Mol. Mass.290.42
SMILESCC1C(=O)SC(C)(Cc2ccc(cc2)C(C)(C)C)C1=O
Structure
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