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TargetBeta-ketoacyl-ACP synthase III (FabH)
LigandBDBM50180122
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330090
IC50 100000±n/a nM
Citation Kim PZhang YMShenoy GNguyen QABoshoff HIManjunatha UHGoodwin MBLonsdale JPrice ACMiller DJDuncan KWhite SWRock COBarry CEDowd CS Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem 49:159-71 (2006) [PubMed]  Article
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Beta-ketoacyl-ACP synthase III (FabH)
Name:Beta-ketoacyl-ACP synthase III (FabH)
Synonyms:3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III
Type:Enzyme
Mol. Mass.:33506.68
Organism:Escherichia coli
Description:C3TDZ2
Residue:317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAAT
RAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALS
VADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLH
ADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDW
LVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVL
LEAFGGGFTWGSALVRF
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  Blast E-value cutoff:
BDBM50180122
n/a
NameBDBM50180122
Synonyms:3,5-dimethyl-4-hydroxy-5-(1-methylundecyl)-5H-thiophen-2-one | CHEMBL199976
TypeSmall organic molecule
Emp. Form.C18H32O2S
Mol. Mass.312.51
SMILESCCCCCCCCCCC(C)C1(C)SC(=O)C(C)C1=O
Structure
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