Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50181499

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_330376 (CHEMBL853024)

59±n/a nM

Citation

Hogan, K; Peluso, S; Gould, S; Parsons, I; Ryan, D; Wu, L; Visiers, I Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3.28(125), I3.32(129), and I7.42(291) is critical for receptor activation. J Med Chem49:911-22 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50181499

n/a

Name

BDBM50181499

Synonyms:

CHEMBL438596 | c[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro]

Type

Small organic molecule

Emp. Form.

C63H84N16O14

Mol. Mass.

1289.4399

SMILES

CC[C@@H](C)[C@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C1=O)[C@@H](C)O)[C@@H](C)O |wU:62.66,26.28,80.89,8.96,90.98,74.79,2.2,48.51,wD:37.39,12.12,58.93,87.95,4.3,(-.04,-39.96,;-.01,-38.42,;-1.33,-37.63,;-2.68,-38.38,;-1.3,-36.09,;.04,-35.34,;1.36,-36.14,;1.34,-37.68,;2.71,-35.39,;4.03,-36.19,;5.38,-35.44,;5.41,-33.9,;6.7,-36.23,;6.67,-37.77,;7.99,-38.57,;7.25,-39.94,;8.31,-41.05,;9.69,-40.37,;11.12,-40.95,;12.33,-40.01,;12.12,-38.48,;10.7,-37.9,;9.48,-38.85,;8.05,-35.49,;9.36,-36.28,;9.34,-37.82,;10.71,-35.54,;12.03,-36.33,;13.38,-35.58,;14.7,-36.38,;16.05,-35.63,;17.37,-36.43,;18.71,-35.68,;17.34,-37.97,;10.74,-34,;12.09,-33.25,;13.41,-34.04,;12.11,-31.71,;13.46,-30.96,;14.78,-31.76,;14.74,-33.3,;16.06,-34.09,;17.41,-33.35,;17.44,-31.8,;16.12,-31.01,;10.8,-30.92,;10.82,-29.38,;12.17,-28.63,;9.5,-28.58,;9.53,-27.04,;10.88,-26.3,;12.27,-26.95,;13.34,-25.83,;12.6,-24.49,;11.06,-24.78,;8.16,-29.33,;6.84,-28.53,;6.86,-27,;5.49,-29.28,;4.17,-28.49,;2.82,-29.23,;2.79,-30.77,;1.5,-28.44,;1.53,-26.9,;2.88,-26.15,;4.19,-26.95,;5.54,-26.21,;5.57,-24.67,;6.92,-23.92,;4.24,-23.87,;2.9,-24.62,;.16,-29.18,;-1.16,-28.39,;-1.14,-26.85,;-2.51,-29.14,;-3.83,-28.34,;-3.8,-26.8,;-2.54,-30.68,;-4.07,-30.84,;-5,-29.56,;-4.68,-32.25,;-6.18,-32.58,;-6.32,-34.06,;-4.9,-34.71,;-3.89,-33.56,;-2.62,-35.3,;-3.97,-36.04,;5.46,-30.82,;4.11,-31.57,;6.78,-31.61,;2.74,-33.85,;1.42,-33.06,;4.09,-33.11,)|

Structure