Reaction Details |
| Report a problem with these data |
Target | Prothrombin |
---|
Ligand | BDBM50177421 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_334615 (CHEMBL862522) |
---|
IC50 | 39±n/a nM |
---|
Citation | Hanessian, S; Therrien, E; van Otterlo, WA; Bayrakdarian, M; Nilsson, I; Fjellström, O; Xue, Y Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Bioorg Med Chem Lett16:1032-6 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prothrombin |
---|
Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
BDBM50177421 |
---|
n/a |
---|
Name | BDBM50177421 |
Synonyms: | CHEMBL558235 | N-(4-carbamimidoylbenzyl)-2-(3-(3,4-dimethoxyphenylsulfonamido)-2-hydroxy-6-methylphenyl)acetamide hydrochloride |
Type | Small organic molecule |
Emp. Form. | C25H28N4O6S |
Mol. Mass. | 512.578 |
SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(C)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1O |
Structure |
|