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TargetGag-Pol polyprotein [489-587]
LigandBDBM50178815
Substrate/Competitorn/a
Meas. Tech.ChEMBL_340965 (CHEMBL866517)
Ki 2.4±n/a nM
Citation Ekegren, JKGinman, NJohansson, AWallberg, HLarhed, MSamuelsson, BUnge, THallberg, A Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold. J Med Chem49:1828-32 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [489-587]
Name:Gag-Pol polyprotein [489-587]
Synonyms:Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:P04585[489-587]
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50178815
n/a
NameBDBM50178815
Synonyms:((1S)-1-{N'-(4-Bromo-benzyl)-N'-[(2S)-2-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-phenyl-propyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester | 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE | CHEMBL197500 | Methyl(S)-1-(((S)-2-benzyl-2-hydroxy-3-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-ylamino)-3-oxopropyl)(4-bromobenzyl)amino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate | {(1S)-1-[N'-(4-bromo-benzyl)-N'-[(2S)-2-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-phenyl-propyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester
TypeSmall organic molecule
Emp. Form.C34H41BrN4O6
Mol. Mass.681.617
SMILESCOC(=O)N[C@H](C(=O)NN(Cc1ccc(Br)cc1)C[C@@](O)(Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)C(C)(C)C
Structure
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