| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50180523 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_344145 (CHEMBL868869) |
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| Ki | 11.9±n/a nM |
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| Citation |  Cases-Thomas, MJ; Masters, JJ; Walter, MW; Campbell, G; Haughton, L; Gallagher, PT; Dobson, DR; Mancuso, V; Bonnier, B; Giard, T; Defrance, T; Vanmarsenille, M; Ledgard, A; White, C; Ouwerkerk-Mahadevan, S; Brunelle, FJ; Dezutter, NA; Herbots, CA; Lienard, JY; Findlay, J; Hayhurst, L; Boot, J; Thompson, LK; Hemrick-Luecke, S Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter. Bioorg Med Chem Lett16:2022-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50180523 |
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| n/a |
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| Name | BDBM50180523 |
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| Synonyms: | (R)-2-(2-bromophenyl)-1-((S)-morpholin-2-yl)-1-phenylethanol | CHEMBL206521 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20BrNO2 |
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| Mol. Mass. | 362.261 |
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| SMILES | O[C@@](Cc1ccccc1Br)([C@@H]1CNCCO1)c1ccccc1 |
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| Structure | 
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