| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase |
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| Ligand | BDBM10885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_347177 (CHEMBL862664) |
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| Ki | 246±n/a nM |
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| Citation |  Nishimori, I; Vullo, D; Minakuchi, T; Morimoto, K; Onishi, S; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori. Bioorg Med Chem Lett16:2182-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase |
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| Name: | Carbonic anhydrase |
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| Synonyms: | Beta-carbonic anhydrase | CYNT_HELPY | Carbonic anhydrase 1 | cynT | hpβCA |
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| Type: | Protein |
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| Mol. Mass.: | 25517.77 |
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| Organism: | Helicobacter pylori (strain G27) |
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| Description: | O24855 |
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| Residue: | 221 |
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| Sequence: | MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVIC
NMGNVNPPKTSYKESLSTIASIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKT
PYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNARLQLNNLLSYDFIQEKASKNE
LKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF
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| BDBM10885 |
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| n/a |
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| Name | BDBM10885 |
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| Synonyms: | (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide | (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide | AL-4862 | Azopt | Brinzolamide (BRZ) | brinzolamide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H21N3O5S3 |
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| Mol. Mass. | 383.507 |
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| SMILES | CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
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| Structure | 
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