Ki Summary

Reaction Details

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Target

3-oxoacyl-acyl-carrier protein reductase

Ligand

BDBM50153015

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_361105 (CHEMBL859171)

IC50

1000±n/a nM

Citation

Tasdemir, D; Lack, G; Brun, R; Rüedi, P; Scapozza, L; Perozzo, R Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem49:3345-53 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

3-oxoacyl-acyl-carrier protein reductase

Name:

3-oxoacyl-acyl-carrier protein reductase

Synonyms:

n/a

Type:

PROTEIN

Mol. Mass.:

33333.53

Organism:

Plasmodium falciparum

Description:

ChEMBL_675156

Residue:

301

Sequence:

MSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGEN
KVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSK
KEEISEVINKILTEHKNVDILVSNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPIS
KRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPG
FISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLS
P

BDBM50153015

n/a

Name

BDBM50153015

Synonyms:

(-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-gallate | (-)-epicatechin gallate | (-)-epicatechingallate | (-)epicatechingallate | (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate | 3,4,5-Trihydroxy-benzoic acid (2R,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester | 3,4,5-Trihydroxy-benzoic acid 2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester | CHEMBL36327 | Epicatechin gallate | Epicatechin-3-O-gallate

Type

Small organic molecule

Emp. Form.

C22H18O10

Mol. Mass.

442.3723

SMILES

Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1ccc(O)c(O)c1 |r|

Structure