| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmin |
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| Ligand | BDBM50368125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_365492 (CHEMBL867908) |
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| EC50 | 21000±n/a nM |
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| Citation |  Ge, J; Normant, E; Porter, JR; Ali, JA; Dembski, MS; Gao, Y; Georges, AT; Grenier, L; Pak, RH; Patterson, J; Sydor, JR; Tibbitts, TT; Tong, JK; Adams, J; Palombella, VJ Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem49:4606-15 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmin |
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| Name: | Endoplasmin |
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| Synonyms: | ENPL_CANLF | GRP94 | HSP90B1 | Heat shock protein 90 beta | TRA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92464.42 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_1478277 |
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| Residue: | 804 |
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| Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEDSDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEDDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPSDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAIEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIKDMLRRVKEDEDDKTVSDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETTEDTTEDTEQDDEE
EMDAGTDDEEQETVKKSTAEKDEL
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| BDBM50368125 |
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| n/a |
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| Name | BDBM50368125 |
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| Synonyms: | ADENOSINE DIPHOSPHATE | ADP |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N5O10P2 |
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| Mol. Mass. | 427.2011 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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