Reaction Details |
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Target | Endoplasmin |
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Ligand | BDBM15359 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_365492 (CHEMBL867908) |
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EC50 | 124±n/a nM |
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Citation | Ge, J; Normant, E; Porter, JR; Ali, JA; Dembski, MS; Gao, Y; Georges, AT; Grenier, L; Pak, RH; Patterson, J; Sydor, JR; Tibbitts, TT; Tong, JK; Adams, J; Palombella, VJ Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem49:4606-15 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endoplasmin |
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Name: | Endoplasmin |
Synonyms: | ENPL_CANLF | GRP94 | HSP90B1 | Heat shock protein 90 beta | TRA1 |
Type: | PROTEIN |
Mol. Mass.: | 92464.42 |
Organism: | Canis familiaris |
Description: | ChEMBL_1478277 |
Residue: | 804 |
Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEDSDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEDDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPSDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAIEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIKDMLRRVKEDEDDKTVSDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETTEDTTEDTEQDDEE
EMDAGTDDEEQETVKKSTAEKDEL
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BDBM15359 |
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n/a |
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Name | BDBM15359 |
Synonyms: | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate | 17-(Allylamino)geldanamycin | 17-AAG | 17AAG | CHEMBL109480 | GLD-36 | Tanespimycin |
Type | Small organic molecule |
Emp. Form. | C31H43N3O8 |
Mol. Mass. | 585.6884 |
SMILES | CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C |r,w:16.16,38.39,t:28| |
Structure |
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