| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 2 |
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| Ligand | BDBM50183063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_368942 (CHEMBL869061) |
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| IC50 | 532000±n/a nM |
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| Citation |  Vlahakis, JZ; Kinobe, RT; Bowers, RJ; Brien, JF; Nakatsu, K; Szarek, WA Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem49:4437-41 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 2 |
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| Name: | Heme oxygenase 2 |
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| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35754.99 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
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| Residue: | 315 |
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| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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| BDBM50183063 |
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| n/a |
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| Name | BDBM50183063 |
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| Synonyms: | (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane hydrochloride | 1-(((2R,4R)-2-(4-chlorophenethyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | CHEMBL536056 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19ClN2O2 |
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| Mol. Mass. | 306.787 |
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| SMILES | C[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1 |
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| Structure | 
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