Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50190370 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_376241 (CHEMBL869294) |
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Ki | 50±n/a nM |
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Citation | Zhang, Q; Keenan, SM; Peng, Y; Nair, AC; Yu, SJ; Howells, RD; Welsh, WJ Discovery of novel triazole-based opioid receptor antagonists. J Med Chem49:4044-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50190370 |
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n/a |
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Name | BDBM50190370 |
Synonyms: | 1-{3-[4-(tert-butyl) phenyl]-5-N,N-dimethylamino-(1,2,4-triazol-4-yl)}-3-phenol | CHEMBL377904 |
Type | Small organic molecule |
Emp. Form. | C20H24N4O |
Mol. Mass. | 336.4308 |
SMILES | CN(C)c1nnc(-c2ccc(cc2)C(C)(C)C)n1-c1cccc(O)c1 |
Structure |
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