| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orotidine 5'-phosphate decarboxylase |
|---|
| Ligand | BDBM21338 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_381849 (CHEMBL869171) |
|---|
| Ki | 840±n/a nM |
|---|
| Citation |  Poduch, E; Bello, AM; Tang, S; Fujihashi, M; Pai, EF; Kotra, LP Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem49:4937-45 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orotidine 5'-phosphate decarboxylase |
|---|
| Name: | Orotidine 5'-phosphate decarboxylase |
|---|
| Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 24909.45 |
|---|
| Organism: | Methanobacterium thermoautotrophicum |
|---|
| Description: | n/a |
|---|
| Residue: | 228 |
|---|
| Sequence: | MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
|
|
|
|---|
| BDBM21338 |
|---|
| n/a |
|---|
| Name | BDBM21338 |
|---|
| Synonyms: | 6-Amino-uridine 5-O-Monophosphate | C6-Uridine Derivative, 15 | JMC521648 Compound 37 | {[(2R,3S,4R,5R)-5-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H14N3O9P |
|---|
| Mol. Mass. | 339.1959 |
|---|
| SMILES | Nc1cc(=O)[nH]c(=O)n1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
