Reaction Details |
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Target | Orotidine-5'-phosphate decarboxylase |
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Ligand | BDBM21340 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_381851 (CHEMBL869173) |
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Ki | 1000±n/a nM |
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Citation | Poduch, E; Bello, AM; Tang, S; Fujihashi, M; Pai, EF; Kotra, LP Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem49:4937-45 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orotidine-5'-phosphate decarboxylase |
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Name: | Orotidine-5'-phosphate decarboxylase |
Synonyms: | ODCase | Orotidine 5-Phosphate Decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) |
Type: | Enzyme |
Mol. Mass.: | 37826.43 |
Organism: | Plasmodium falciparum (malaria parasite P. falciparum) |
Description: | n/a |
Residue: | 323 |
Sequence: | MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEKYINNVSIKK
DILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTFKMNFAFYIPYGSVGIDVLK
NVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDE
EKNKYYSAFVLVKTTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFV
VGANSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNP
YPQKAAQMYYDQINAILKQNMES
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BDBM21340 |
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n/a |
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Name | BDBM21340 |
Synonyms: | 6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C8H12N3O9P |
Mol. Mass. | 325.1693 |
SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O |r| |
Structure |
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