| Reaction Details |
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 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
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| Ligand | BDBM50193407 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_382280 (CHEMBL866784) |
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| IC50 | 5400±n/a nM |
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| Citation |  Kessler, A; Faure, H; Petrel, C; Rognan, D; Césario, M; Ruat, M; Dauban, P; Dodd, RH N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J Med Chem49:5119-28 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Extracellular calcium-sensing receptor |
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| Name: | Extracellular calcium-sensing receptor |
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| Synonyms: | CASR_RAT | Calcium sensing receptor | Casr | Gprc2a | Parathyroid Cell calcium-sensing receptor | Pcar1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120858.46 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_750426 |
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| Residue: | 1079 |
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| Sequence: | MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQY
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWA
SSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIA
KEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQILICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSS
SLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQ
PRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCA
DADSEMTIQETGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS
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| BDBM50193407 |
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| n/a |
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| Name | BDBM50193407 |
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| Synonyms: | CHEMBL537426 | N1-[4-(trifluoromethoxy)benzenesulfonyl)-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexane hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F3N2O3S |
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| Mol. Mass. | 492.554 |
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| SMILES | CC(N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12 |
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| Structure | 
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