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TargetGNAT family acetyltransferase
LigandBDBM50193480
Substrate/Competitorn/a
Meas. Tech.ChEMBL_385423 (CHEMBL869194)
Ki 12±n/a nM
Citation Gao, FYan, XShakya, TBaettig, OMAit-Mohand-Brunet, SBerghuis, AMWright, GDAuclair, K Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. J Med Chem49:5273-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GNAT family acetyltransferase
Name:GNAT family acetyltransferase
Synonyms:Aminoglycoside acetyltransferase
Type:PROTEIN
Mol. Mass.:21017.80
Organism:Enterococcus durans
Description:ChEMBL_385423
Residue:183
Sequence:
MIISEFDRDNLVLRDQLADLLRLTWPDEYGEQPMKEVERLLEDERIAVSAIEGDELIGFV
GAIPQYGQTGWELHPLVVESMYRKQQVGTRLVSYLEKEIASQGGIVVYLGTDDVEGQTSL
AIEEDLFEDTFDKLETIQNRKDHPYEFYEKLGYQIVGVIPDANGWNKPDIWMAKRIARKH
GSE
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BDBM50193480
n/a
NameBDBM50193480
Synonyms:(R)-4-(3-(2-(2-(((2R,3S,4R,5R,6R)-5-amino-6-((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyloxy)-3,4-dihydroxy-tetrahydro-2H-pyran-2-yl)methylamino)-2-oxoethylthio)ethylamino)-3-oxopropylamino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate | CHEMBL373488
TypeSmall organic molecule
Emp. Form.C25H49N6O14PS
Mol. Mass.720.727
SMILESCC(C)(COP(O)(O)=O)[C@@H](O)C(=O)NCCC(=O)NCCSCC(=O)NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Structure
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