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TargetSodium-dependent noradrenaline transporter
LigandBDBM50124566
Substrate/Competitorn/a
Meas. Tech.ChEMBL_390293 (CHEMBL869835)
IC50 11±n/a nM
Citation Jonathan Fray, MBish, GBrown, ADFish, PVStobie, AWakenhut, FWhitlock, GA N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett16:4345-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50124566
n/a
NameBDBM50124566
Synonyms:(R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine | 2-[2-ethoxyphenoxy(phenyl)methyl]-1,4-oxazinane | CHEMBL14370 | REBOXETINE | rac-syn-2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine
TypeSmall organic molecule
Emp. Form.C19H23NO3
Mol. Mass.313.3908
SMILESCCOc1ccccc1OC(C1CNCCO1)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: