Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50370757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_392922 (CHEMBL870416) |
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Ki | 170±n/a nM |
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Citation | Wentland, MP; VanAlstine, M; Kucejko, R; Lou, R; Cohen, DJ; Parkhill, AL; Bidlack, JM Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine. J Med Chem49:5635-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50370757 |
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n/a |
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Name | BDBM50370757 |
Synonyms: | CHEMBL1162933 |
Type | Small organic molecule |
Emp. Form. | C32H36N2O |
Mol. Mass. | 464.641 |
SMILES | CC1C2Cc3ccc(cc3C1(C)CCN2CC1CC1)C(=O)NCc1ccc(cc1)-c1ccccc1 |THB:0:1:3.4.9:14.12.13,5:4:1:14.12.13,8:9:1:14.12.13,15:14:1:3.4.9| |
Structure |
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