| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50190017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_398762 (CHEMBL908034) |
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| IC50 | 10±n/a nM |
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| Citation |  Wood, J; Bagi, CM; Akuche, C; Bacchiocchi, A; Baryza, J; Blue, ML; Brennan, C; Campbell, AM; Choi, S; Cook, JH; Conrad, P; Dixon, BR; Ehrlich, PP; Gane, T; Gunn, D; Joe, T; Johnson, JS; Jordan, J; Kramss, R; Liu, P; Levy, J; Lowe, DB; McAlexander, I; Natero, R; Redman, AM; Scott, WJ; Town, C; Wang, M; Wang, Y; Zhang, Z 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate. Bioorg Med Chem Lett16:4965-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
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| Type: | Oxidoreductase; single-pass type II membrane protein |
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| Mol. Mass.: | 42795.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme was partially purified from human placenta. |
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| Residue: | 387 |
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| Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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| BDBM50190017 |
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| n/a |
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| Name | BDBM50190017 |
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| Synonyms: | (4R,5R)-4-(2-fluorophenyl)-5-((S)-hydroxy(5-phenylthiophen-2-yl)methyl)-1-methylpyrrolidin-2-one | CHEMBL383970 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20FNO2S |
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| Mol. Mass. | 381.463 |
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| SMILES | CN1[C@@H]([C@H](O)c2ccc(s2)-c2ccccc2)[C@H](CC1=O)c1ccccc1F |
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| Structure | 
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