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Target17-beta-hydroxysteroid dehydrogenase type 2
LigandBDBM50190020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_398762 (CHEMBL908034)
IC50 30±n/a nM
Citation Wood, JBagi, CMAkuche, CBacchiocchi, ABaryza, JBlue, MLBrennan, CCampbell, AMChoi, SCook, JHConrad, PDixon, BREhrlich, PPGane, TGunn, DJoe, TJohnson, JSJordan, JKramss, RLiu, PLevy, JLowe, DBMcAlexander, INatero, RRedman, AMScott, WJTown, CWang, MWang, YZhang, Z 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate. Bioorg Med Chem Lett16:4965-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
17-beta-hydroxysteroid dehydrogenase type 2
Name:17-beta-hydroxysteroid dehydrogenase type 2
Synonyms:17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase
Type:Oxidoreductase; single-pass type II membrane protein
Mol. Mass.:42795.29
Organism:Homo sapiens (Human)
Description:Enzyme was partially purified from human placenta.
Residue:387
Sequence:
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50190020
n/a
NameBDBM50190020
Synonyms:4-(5-((S)-hydroxy((2R,3R)-1-methyl-5-oxo-3-phenylpyrrolidin-2-yl)methyl)thiophen-2-yl)benzonitrile | CHEMBL379484
TypeSmall organic molecule
Emp. Form.C23H20N2O2S
Mol. Mass.388.482
SMILESCN1[C@@H]([C@H](O)c2ccc(s2)-c2ccc(cc2)C#N)[C@H](CC1=O)c1ccccc1
Structure
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