| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50189976 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_405298 (CHEMBL869858) |
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| IC50 | 4710±n/a nM |
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| Citation |  Srivastava, V; Saxena, HO; Shanker, K; Kumar, JK; Luqman, S; Gupta, MM; Khanuja, SP; Negi, AS Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors. Bioorg Med Chem Lett16:4603-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50189976 |
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| n/a |
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| Name | BDBM50189976 |
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| Synonyms: | CHEMBL212492 | N-(4-methoxyphenyl)-4-(1-(3,4,5-trimethoxybenzoyl)naphthalen-2-yloxy)but-2-enamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29NO7 |
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| Mol. Mass. | 527.5645 |
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| SMILES | COc1ccc(NC(=O)\C=C\COc2ccc3ccccc3c2C(=O)c2cc(OC)c(OC)c(OC)c2)cc1 |
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| Structure | 
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