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TargetCathepsin D
LigandBDBM50189981
Substrate/Competitorn/a
Meas. Tech.ChEMBL_405298
IC50 60±n/a nM
Citation Srivastava VSaxena HOShanker KKumar JKLuqman SGupta MMKhanuja SPNegi AS Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors. Bioorg Med Chem Lett 16:4603-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin D
Name:Cathepsin D
Synonyms:Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:Enzyme
Mol. Mass.:44551.72
Organism:Homo sapiens (Human)
Description:Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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  Blast E-value cutoff:
BDBM50189981
n/a
NameBDBM50189981
Synonyms:2-[1-(3,4,5-trimethoxybenzoyl)naphthalen-2-yloxy]ethanoic acid | CHEMBL212787
TypeSmall organic molecule
Emp. Form.C22H20O7
Mol. Mass.396.39
SMILESCOc1cc(cc(OC)c1OC)C(=O)c1c(OCC(O)=O)ccc2ccccc12
Structure
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