| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50195593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_414098 (CHEMBL908314) |
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| IC50 | 4±n/a nM |
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| Citation |  Semeraro, T; Lossani, A; Botta, M; Ghiron, C; Alvarez, R; Manetti, F; Mugnaini, C; Valensin, S; Focher, F; Corelli, F Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. J Med Chem49:6037-45 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50195593 |
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| n/a |
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| Name | BDBM50195593 |
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| Synonyms: | 2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one diacetate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N5O2 |
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| Mol. Mass. | 263.2957 |
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| SMILES | Nc1nc2c(CN3CCC[C@H]3CO)c[nH]c2c(=O)[nH]1 |
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| Structure | 
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