| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50199898 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_422446 (CHEMBL909320) |
|---|
| Ki | 100±n/a nM |
|---|
| Citation |  Le Bourdonnec, B; Goodman, AJ; Michaut, M; Ye, HF; Graczyk, TM; Belanger, S; Herbertz, T; Yap, GP; DeHaven, RN; Dolle, RE Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. J Med Chem49:7278-89 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42648.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41145 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
|
|
|
|---|
| BDBM50199898 |
|---|
| n/a |
|---|
| Name | BDBM50199898 |
|---|
| Synonyms: | 3-((1R,2R,7R,9-alpha-S)-1,2-dimethyl-7-phenyl-octahydro-1H-quinolizin-2-yl)phenol | CHEMBL385392 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29NO |
|---|
| Mol. Mass. | 335.4825 |
|---|
| SMILES | C[C@H]1[C@@H]2CC[C@@H](CN2CC[C@@]1(C)c1cccc(O)c1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
