Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50200828 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_422598 (CHEMBL911626) |
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IC50 | 3±n/a nM |
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Citation | Lin, LS; Lanza, TJ; Jewell, JP; Liu, P; Shah, SK; Qi, H; Tong, X; Wang, J; Xu, SS; Fong, TM; Shen, CP; Lao, J; Xiao, JC; Shearman, LP; Stribling, DS; Rosko, K; Strack, A; Marsh, DJ; Feng, Y; Kumar, S; Samuel, K; Yin, W; Van der Ploeg, LH; Goulet, MT; Hagmann, WK Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J Med Chem49:7584-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52868.96 |
Organism: | Homo sapiens (Human) |
Description: | P21554 |
Residue: | 472 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50200828 |
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n/a |
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Name | BDBM50200828 |
Synonyms: | CHEMBL218649 | N-[(1R,2R)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-chloropyridyloxy)-2-methylpropanamide | N-[(1S,2S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-chloropyridyloxy)-2-methylpropanamide |
Type | Small organic molecule |
Emp. Form. | C26H27Cl2NO2 |
Mol. Mass. | 456.404 |
SMILES | C[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)[C@@H](Cc1ccc(Cl)cc1)c1ccccc1 |r| |
Structure |
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