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TargetC-X-C chemokine receptor type 1
LigandBDBM50200876
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422685 (CHEMBL912816)
IC50 3058±n/a nM
Citation Dwyer, MPYu, YChao, JAki, CChao, JBiju, PGirijavallabhan, VRindgen, DBond, RMayer-Ezel, RJakway, JHipkin, RWFossetta, JGonsiorek, WBian, HFan, XTerminelli, CFine, JLundell, DMerritt, JRRokosz, LLKaiser, BLi, GWang, WStauffer, TOzgur, LBaldwin, JTaveras, AG Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist. J Med Chem49:7603-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 1
Name:C-X-C chemokine receptor type 1
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50200876
n/a
NameBDBM50200876
Synonyms:(S)-3-(3,4-dioxo-2-(1-phenylethylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL219472
TypeSmall organic molecule
Emp. Form.C21H21N3O4
Mol. Mass.379.4091
SMILESC[C@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Structure
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