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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM50201949
Substrate/Competitorn/a
Meas. Tech.ChEMBL_423284 (CHEMBL855443)
IC50 10±n/a nM
Citation Kaila, NJanz, KDeBernardo, SBedard, PWCamphausen, RTTam, STsao, DHKeith, JCNickerson-Nutter, CShilling, AYoung-Sciame, RWang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem50:21-39 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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  Blast E-value cutoff:
BDBM50201949
n/a
NameBDBM50201949
Synonyms:2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic acid | CHEMBL219648
TypeSmall organic molecule
Emp. Form.C22H15NO3
Mol. Mass.341.3594
SMILESOC(=O)c1c(O)c(nc2ccccc12)-c1ccc(cc1)-c1ccccc1
Structure
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