Reaction Details |
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Target | Prostacyclin receptor |
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Ligand | BDBM50193924 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424243 (CHEMBL909017) |
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Ki | >500±n/a nM |
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Citation | Belley, M; Chan, CC; Gareau, Y; Gallant, M; Juteau, H; Houde, K; Lachance, N; Labelle, M; Sawyer, N; Tremblay, N; Lamontagne, S; Carrière, MC; Denis, D; Greig, GM; Slipetz, D; Gordon, R; Chauret, N; Li, C; Zamboni, RJ; Metters, KM Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett16:5639-42 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostacyclin receptor |
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Name: | Prostacyclin receptor |
Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40968.22 |
Organism: | Homo sapiens (Human) |
Description: | The membranes prepared from human platelet were used in binding assay. |
Residue: | 386 |
Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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BDBM50193924 |
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n/a |
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Name | BDBM50193924 |
Synonyms: | 3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)acrylic acid | CHEMBL218263 |
Type | Small organic molecule |
Emp. Form. | C27H22O3 |
Mol. Mass. | 394.4618 |
SMILES | OC(=O)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 |
Structure |
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