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TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase
LigandBDBM50024894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_424365 (CHEMBL911296)
IC50 118±n/a nM
Citation Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett16:5605-9 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Name:UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:Protein
Mol. Mass.:44814.62
Organism:Escherichia coli K-12 (Enterobacteria)
Description:E. coli MurA
Residue:419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
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  Blast E-value cutoff:
BDBM50024894
n/a
NameBDBM50024894
Synonyms:(1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)-3-methyloxiran-2-ylphosphonate | (2R,3S)-3-methyloxiran-2-ylphosphonic acid | (3-Methyl-oxiranyl)-phosphonic acid(Na salt) | CHEMBL1757 | FOSFOMYCIN | Fosfomycin (compound 1) | Fosfomycin Calcium | Fosfomycin Sodium | Monurol | phosphomycin
TypeSmall organic molecule
Emp. Form.C3H7O4P
Mol. Mass.138.059
SMILESC[C@@H]1O[C@@H]1P(O)(O)=O |r|
Structure
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