| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Ligand | BDBM50096873 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_424366 (CHEMBL911297) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett16:5605-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Synonyms: | EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 44640.67 |
|---|
| Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
|---|
| Description: | P. aeruginosa MurA |
|---|
| Residue: | 421 |
|---|
| Sequence: | MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM
GVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIG
SRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALAN
GRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGT
YLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTA
PYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGV
PKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVP
G
|
|
|
|---|
| BDBM50096873 |
|---|
| n/a |
|---|
| Name | BDBM50096873 |
|---|
| Synonyms: | (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one | Alantolactone | CHEMBL136356 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H20O2 |
|---|
| Mol. Mass. | 232.3181 |
|---|
| SMILES | C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12 |r,t:16| |
|---|
| Structure | 
|
|---|
Search and Browse
