Reaction Details |
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Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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Ligand | BDBM50194429 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424366 (CHEMBL911297) |
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IC50 | 27800±n/a nM |
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Citation | Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett16:5605-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
Synonyms: | EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA |
Type: | Protein |
Mol. Mass.: | 44640.67 |
Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
Description: | P. aeruginosa MurA |
Residue: | 421 |
Sequence: | MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM
GVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIG
SRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALAN
GRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGT
YLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTA
PYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGV
PKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVP
G
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BDBM50194429 |
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n/a |
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Name | BDBM50194429 |
Synonyms: | (-)-parthenolide | (1aR,7aS,10aS,10bS,Z)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8-hexahydro-11-oxa-bicyclo[8.1.0]undeca-1(10),4-dieno[9,8-b]furan-9(1aH,10aH,10bH)-one | (Z)-(1S,2S,4R,11S)-4,8-Dimethyl-12-methylene-3,14-dioxa-tricyclo[9.3.0.0*2,4*]tetradec-7-en-13-one | CHEMBL540445 | PARTHENOLIDE |
Type | Small organic molecule |
Emp. Form. | C15H20O3 |
Mol. Mass. | 248.3175 |
SMILES | C\C1=C\CC[C@@]2(C)O[C@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1 |r,t:1| |
Structure |
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