| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Ligand | BDBM50411242 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_424366 (CHEMBL911297) |
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| IC50 | >50000±n/a nM |
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| Citation |  Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett16:5605-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Synonyms: | EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA |
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| Type: | Protein |
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| Mol. Mass.: | 44640.67 |
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| Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
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| Description: | P. aeruginosa MurA |
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| Residue: | 421 |
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| Sequence: | MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM
GVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIG
SRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALAN
GRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGT
YLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTA
PYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGV
PKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVP
G
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| BDBM50411242 |
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| n/a |
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| Name | BDBM50411242 |
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| Synonyms: | CHEMBL86416 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20O2 |
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| Mol. Mass. | 232.3181 |
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| SMILES | C\C1=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]2CC1 |r,c:1,t:6| |
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| Structure | 
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