Ki Summary

Reaction Details

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Target

Sodium- and chloride-dependent glycine transporter 1

Ligand

BDBM50195181

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_424804 (CHEMBL909053)

IC50

19±n/a nM

Citation

Zhao, Z; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Wolkenberg, SE; Lindsley, CW Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorg Med Chem Lett16:5968-72 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sodium- and chloride-dependent glycine transporter 1

Name:

Sodium- and chloride-dependent glycine transporter 1

Synonyms:

GlyT-1 | Glyt1 | SC6A9_MOUSE | Slc6a9 | Solute carrier family 6 member 9

Type:

PROTEIN

Mol. Mass.:

76552.86

Organism:

Mus musculus

Description:

ChEMBL_1351579

Residue:

692

Sequence:

MIGGDTRAASAHPGMASAQGPVATPSPEQPFPGTTSVSLARPVLRVWHGAHSSGLLPNLI
AQHSPAMAQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG
GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGI
YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHL
FNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGK
VVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC
AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD
HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWIL
QKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHR
NYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGF
LMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSP
EDGFEVQPLHPDKAQIPIVGSNGSSRFQDSRI

BDBM50195181

n/a

Name

BDBM50195181

Synonyms:

2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide | CHEMBL223199

Type

Small organic molecule

Emp. Form.

C21H28Cl2FN3O5S

Mol. Mass.

524.434

SMILES

CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1

Structure