| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
|---|
| Ligand | BDBM50133496 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_428428 (CHEMBL919497) |
|---|
| IC50 | 17000±n/a nM |
|---|
| Citation |  Jelic, D; Mildner, B; Kostrun, S; Nujic, K; Verbanac, D; Culic, O; Antolovic, R; Brandt, W Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes. J Med Chem50:1090-100 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fyn |
|---|
| Name: | Tyrosine-protein kinase Fyn |
|---|
| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60762.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06241 |
|---|
| Residue: | 537 |
|---|
| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
|
|
|
|---|
| BDBM50133496 |
|---|
| n/a |
|---|
| Name | BDBM50133496 |
|---|
| Synonyms: | (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid | (R)-rosmarinic acid | CHEMBL324842 | Rosmarinic acid, 2 | US10688093, Compound rosmarinic acid | US11701353, rosmarinic acid | cid_5281792 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16O8 |
|---|
| Mol. Mass. | 360.3148 |
|---|
| SMILES | OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
