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TargetProtein arginine N-methyltransferase 1 [11-371]
LigandBDBM50206427
Substrate/Competitorn/a
Meas. Tech.ChEMBL_428527 (CHEMBL919884)
IC50 92000±n/a nM
Citation Ragno, RSimeoni, SCastellano, SVicidomini, CMai, ACaroli, ATramontano, ABonaccini, CTrojer, PBauer, IBrosch, GSbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem50:1241-53 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 1 [11-371]
Name:Protein arginine N-methyltransferase 1 [11-371]
Synonyms:ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:Protein
Mol. Mass.:41506.52
Organism:Homo sapiens (Human)
Description:Q99873[11-371]
Residue:361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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  Blast E-value cutoff:
BDBM50206427
n/a
NameBDBM50206427
Synonyms:7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) | AMI-1 | CHEMBL221047
TypeSmall organic molecule
Emp. Form.C21H16N2O9S2
Mol. Mass.504.49
SMILESOc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(O)(=O)=O)ccc12)S(O)(=O)=O
Structure
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