Ki Summary

Reaction Details

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Target

Type-2 angiotensin II receptor

Ligand

BDBM50208102

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_429280 (CHEMBL915840)

0.9±n/a nM

Citation

Georgsson, J; Sköld, C; Botros, M; Lindeberg, G; Nyberg, F; Karlén, A; Hallberg, A; Larhed, M Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor. J Med Chem50:1711-5 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Type-2 angiotensin II receptor

Name:

Type-2 angiotensin II receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

41201.61

Organism:

Homo sapiens (Human)

Description:

Angiotensin II, central 0 0::P50052

Residue:

363

Sequence:

MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS

BDBM50208102

n/a

Name

BDBM50208102

Synonyms:

CHEMBL424755 | [4-NH2-Phe6] Ang II

Type

Small organic molecule

Emp. Form.

C50H72N14O12

Mol. Mass.

1061.1933

SMILES

CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(O)=O |wU:8.17,24.32,60.63,47.47,2.2,wD:4.4,20.21,64.66,35.36,(17.7,-20.36,;17.7,-18.82,;16.36,-18.05,;15.03,-18.83,;16.36,-16.51,;15.03,-15.75,;13.7,-16.52,;13.7,-18.06,;12.37,-15.76,;12.36,-14.22,;13.7,-13.44,;15.03,-14.21,;16.36,-13.44,;16.35,-11.9,;17.69,-11.13,;15.01,-11.13,;13.68,-11.91,;11.04,-16.53,;9.71,-15.77,;9.7,-14.23,;8.38,-16.54,;7.05,-15.77,;5.72,-16.54,;5.72,-18.08,;4.39,-15.78,;4.38,-14.24,;3.05,-13.47,;3.04,-11.93,;1.71,-11.17,;1.71,-9.63,;.37,-8.86,;3.04,-8.85,;3.06,-16.55,;1.73,-15.79,;1.72,-14.25,;.4,-16.56,;-.94,-15.79,;.4,-18.1,;-.93,-18.87,;-.93,-20.41,;-2.27,-18.1,;8.38,-18.08,;7.05,-18.85,;9.72,-18.84,;17.69,-15.74,;17.68,-14.2,;19.02,-16.5,;20.35,-15.73,;20.34,-14.19,;21.39,-13.06,;21.08,-11.55,;22.42,-10.8,;23.55,-11.84,;22.91,-13.24,;21.68,-16.5,;21.68,-18.04,;23.01,-15.72,;23.17,-14.19,;24.67,-13.86,;25.44,-15.19,;24.42,-16.34,;24.88,-17.81,;23.84,-18.94,;26.38,-18.15,;26.84,-19.62,;25.51,-20.4,;25.53,-21.94,;24.2,-22.71,;24.22,-24.25,;25.56,-25.01,;25.57,-26.55,;26.89,-24.22,;26.87,-22.68,;28.34,-19.95,;28.81,-21.42,;29.39,-18.82,)|

Structure