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TargetPhenylethanolamine N-methyltransferase
LigandBDBM13014
Substrate/Competitorn/a
Meas. Tech.ChEMBL_430874 (CHEMBL913943)
Ki 1.55±n/a nM
Citation Wu, Q; Gee, CL; Lin, F; Tyndall, JD; Martin, JL; Grunewald, GL; McLeish, MJ Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem48:7243-52 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phenylethanolamine N-methyltransferase
Name:Phenylethanolamine N-methyltransferase
Synonyms:Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:Enzyme
Mol. Mass.:30852.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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BDBM13014
n/a
NameBDBM13014
Synonyms:7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | CHEMBL287837 | CHEMBL541797 | SKF 64139 | tetrahydroisoquinoline (THIQ) analogue
TypeSmall organic molecule
Emp. Form.C9H9Cl2N
Mol. Mass.202.08
SMILESClc1ccc2CCNCc2c1Cl
Structure
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