Reaction Details |
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Target | Tripeptidyl-peptidase 2 |
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Ligand | BDBM50176915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_430943 (CHEMBL914885) |
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Ki | 20000±n/a nM |
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Citation | Ganellin, CR; Bishop, PB; Bambal, RB; Chan, SM; Leblond, B; Moore, AN; Zhao, L; Bourgeat, P; Rose, C; Vargas, F; Schwartz, JC Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem48:7333-42 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tripeptidyl-peptidase 2 |
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Name: | Tripeptidyl-peptidase 2 |
Synonyms: | TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase |
Type: | PROTEIN |
Mol. Mass.: | 138287.08 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_211948 |
Residue: | 1249 |
Sequence: | MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDG
KPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDF
YPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVEL
LNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAE
MLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTR
LSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSA
GNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGAL
GVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRR
ALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQ
VAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVD
PRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIR
RHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIE
AFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLK
YEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSC
PLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDL
DRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIP
KGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEE
FTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAA
NAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQP
HDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLK
FATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
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BDBM50176915 |
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n/a |
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Name | BDBM50176915 |
Synonyms: | (2S)-aminobutyryl-L-proline (S)-sec-butylamide | CHEMBL223718 |
Type | Small organic molecule |
Emp. Form. | C13H25N3O2 |
Mol. Mass. | 255.3565 |
SMILES | CC[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC |r| |
Structure |
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