Ki Summary

Reaction Details

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Target

Adenosine receptor A2b

Ligand

BDBM50205581

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_435759 (CHEMBL904113)

EC50

42.6±n/a nM

Citation

Baraldi, PG; Preti, D; Tabrizi, MA; Fruttarolo, F; Saponaro, G; Baraldi, S; Romagnoli, R; Moorman, AR; Gessi, S; Varani, K; Borea, PA N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor. Bioorg Med Chem15:2514-27 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A2b

Name:

Adenosine receptor A2b

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36341.22

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

332

Sequence:

MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL

BDBM50205581

n/a

Name

BDBM50205581

Synonyms:

(2S,3S,4R,5R)-5-(2-chloro-6-(4-(2-oxo-2-(phenylamino)ethoxy)phenylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide | 1-deoxy-1-[2-chloro-6-{4-[(phenylcarbamoyl)-methoxy]-phenylamino}-9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide | CHEMBL226356

Type

Small organic molecule

Emp. Form.

C26H26ClN7O6

Mol. Mass.

567.981

SMILES

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)Nc4ccccc4)cc3)nc(Cl)nc12

Structure