| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heme oxygenase 1 |
|---|
| Ligand | BDBM50183074 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_435911 (CHEMBL905312) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Roman, G; Riley, JG; Vlahakis, JZ; Kinobe, RT; Brien, JF; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem15:3225-34 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heme oxygenase 1 |
|---|
| Name: | Heme oxygenase 1 |
|---|
| Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 33005.15 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
|---|
| Residue: | 289 |
|---|
| Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
|
|
|
|---|
| BDBM50183074 |
|---|
| n/a |
|---|
| Name | BDBM50183074 |
|---|
| Synonyms: | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol hydrochloride | CHEMBL538578 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H15ClN2O |
|---|
| Mol. Mass. | 250.724 |
|---|
| SMILES | OC(CCc1ccc(Cl)cc1)Cn1ccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
