Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHeme oxygenase 1
LigandBDBM50207199
Substrate/Competitorn/a
Meas. Tech.ChEMBL_435911 (CHEMBL905312)
IC50 1900±n/a nM
Citation Roman, GRiley, JGVlahakis, JZKinobe, RTBrien, JFNakatsu, KSzarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem15:3225-34 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heme oxygenase 1
Name:Heme oxygenase 1
Synonyms:HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:Enzyme
Mol. Mass.:33005.15
Organism:Rattus norvegicus (rat)
Description:HO-1 obtained from rat spleen was used in enzyme assays.
Residue:289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50207199
n/a
NameBDBM50207199
Synonyms:1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | CHEMBL539857
TypeSmall organic molecule
Emp. Form.C15H17BrN2O2
Mol. Mass.337.212
SMILESBrc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: