| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
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| Ligand | BDBM50146518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_436121 (CHEMBL905523) |
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| Ki | 1.50±n/a nM |
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| Citation |  Andrés, JI; Alcázar, J; Alonso, JM; Alvarez, RM; Bakker, MH; Biesmans, I; Cid, JM; De Lucas, AI; Drinkenburg, W; Fernández, J; Font, LM; Iturrino, L; Langlois, X; Lenaerts, I; Martínez, S; Megens, AA; Pastor, J; Pullan, S; Steckler, T Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism. Bioorg Med Chem15:3649-60 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2B adrenergic receptor |
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| Name: | Alpha-2B adrenergic receptor |
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| Synonyms: | ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
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| Type: | Enzyme |
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| Mol. Mass.: | 49964.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18089 |
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| Residue: | 450 |
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| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
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| BDBM50146518 |
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| n/a |
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| Name | BDBM50146518 |
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| Synonyms: | (3R,3aS)-3-{4-[3-(4-Fluoro-phenyl)-2-methyl-allyl]-piperazin-1-ylmethyl}-7,8-dimethoxy-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole | CHEMBL318235 | R-226161 | cis-(+)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole | cis-(+/-)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole | cis-(-)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32FN3O4 |
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| Mol. Mass. | 481.5591 |
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| SMILES | COc1cc2OC[C@H]3[C@H](CN4CCN(C\C(C)=C\c5ccc(F)cc5)CC4)ON=C3c2cc1OC |c:30| |
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| Structure | 
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