| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily B member 1 |
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| Ligand | BDBM50213092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_436811 (CHEMBL905113) |
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| IC50 | 3200±n/a nM |
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| Citation |  Plouvier, B; Beatch, GN; Jung, GL; Zolotoy, A; Sheng, T; Clohs, L; Barrett, TD; Fedida, D; Wang, WQ; Zhu, JJ; Liu, Y; Abraham, S; Lynn, L; Dong, Y; Wall, RA; Walker, MJ Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. J Med Chem50:2818-41 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily B member 1 |
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| Name: | Potassium voltage-gated channel subfamily B member 1 |
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| Synonyms: | DRK1 | Delayed rectifier potassium channel 1 | KCNB1_RAT | Kcnb1 | Voltage-gated potassium channel subunit Kv2.1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95652.47 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_436811 |
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| Residue: | 857 |
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| Sequence: | MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF
TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGESIAKKDKVQD
NHLSPNKWKWTKRALSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYSKMAKTQ
SQPILNTKEMAPQSKPPEELEMSSMPSPVAPLPARTEGVIDMRSMSSIDSFISCATDFPE
ATRFSHSPLASLSSKAGSSTAPEVGWRGALGASGGRLTETNPIPETSRSGFFVESPRSSM
KTNNPLKLRALKVNFVEGDPTPLLPSLGLYHDPLRNRGGAAAAVAGLECASLLDKPVLSP
ESSIYTTASARTPPRSPEKHTAIAFNFEAGVHHYIDTDTDDEGQLLYSVDSSPPKSLHGS
TSPKFSTGARTEKNHFESSPLPTSPKFLRPNCVYSSEGLTGKGPGAQEKCKLENHTPPDV
HMLPGGGAHGSTRDQSI
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| BDBM50213092 |
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| n/a |
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| Name | BDBM50213092 |
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| Synonyms: | (1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cyclohexane | CHEMBL387671 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29NO2 |
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| Mol. Mass. | 339.4712 |
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| SMILES | C(Cc1cccc2ccccc12)O[C@@H]1CCCC[C@H]1N1CCOCC1 |
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| Structure | 
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