Reaction Details |
| Report a problem with these data |
Target | Leucine--tRNA ligase, cytoplasmic |
---|
Ligand | BDBM50370987 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_437249 (CHEMBL906643) |
---|
Kd | 20800±n/a nM |
---|
Citation | Rock, FL; Mao, W; Yaremchuk, A; Tukalo, M; Crépin, T; Zhou, H; Zhang, YK; Hernandez, V; Akama, T; Baker, SJ; Plattner, JJ; Shapiro, L; Martinis, SA; Benkovic, SJ; Cusack, S; Alley, MR An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science316:1759-1761 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Leucine--tRNA ligase, cytoplasmic |
---|
Name: | Leucine--tRNA ligase, cytoplasmic |
Synonyms: | CDC60 | LeuRS | Leucine--tRNA ligase, cytoplasmic | Leucyl-tRNA synthetase | Leucyl-tRNA synthetase, cytoplasmic | SYLC_YEAST |
Type: | PROTEIN |
Mol. Mass.: | 124127.98 |
Organism: | Saccharomyces cerevisiae S288c |
Description: | ChEMBL_437218 |
Residue: | 1090 |
Sequence: | MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFM
SSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKRE
AELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGI
PREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLK
AAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSS
DLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLT
PKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETVIATKGTGVVTCVPSNSPDDY
ITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAK
KIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIV
SLEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLP
WDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEIGPLGISADQMTDEVFDYIFQHQDDV
KNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRAN
GHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRL
FNLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDF
QAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRA
SKPVDKGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQ
SQCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQF
SEIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVP
GNPGVVFQNI
|
|
|
BDBM50370987 |
---|
n/a |
---|
Name | BDBM50370987 |
Synonyms: | TAVABOROLE |
Type | Small organic molecule |
Emp. Form. | C7H6BFO2 |
Mol. Mass. | 151.931 |
SMILES | OB1OCc2cc(F)ccc12 |
Structure |
|