| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Ligand | BDBM50214004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_438958 (CHEMBL889301) |
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| EC50 | 3970±n/a nM |
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| Citation |  Pietranico, SL; Foley, LH; Huby, N; Yun, W; Dunten, P; Vermeulen, J; Wang, P; Toth, K; Ramsey, G; Gubler, ML; Wertheimer, SJ C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg Med Chem Lett17:3835-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Name: | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Synonyms: | Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) | PCKGC_RAT | PEPCK-C | Pck1 | Phosphoenolpyruvate carboxykinase (PEPCK) | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Phosphoenolpyruvate carboxylase |
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| Type: | Protein |
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| Mol. Mass.: | 69414.48 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 622 |
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| Sequence: | MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHM
QEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEE
DFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSV
LEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTL
PGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAW
ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPF
AMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWM
FGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQV
NADLPYEIERELRALKQRISQM
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| BDBM50214004 |
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| n/a |
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| Name | BDBM50214004 |
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| Synonyms: | CHEMBL243116 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29ClFN7O4S |
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| Mol. Mass. | 614.091 |
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| SMILES | CCCCn1c2nc(Cc3ccc(NS(=O)(=O)c4c(C)nn(C)c4Cl)cc3)[nH]c2c(=O)n(Cc2ccccc2F)c1=O |
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| Structure | 
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