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TargetCarbonic anhydrase 12
LigandBDBM12936
Substrate/Competitorn/a
Meas. Tech.ChEMBL_441219 (CHEMBL891443)
Ki 6.1±n/a nM
Citation Wilkinson, BLBornaghi, LFHouston, TAInnocenti, AVullo, DSupuran, CTPoulsen, SA Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett17:987-92 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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  Blast E-value cutoff:
BDBM12936
n/a
NameBDBM12936
Synonyms:4-({[4-(Aminosulfonyl)benzoyl]oxy}methyl-1-(2,3,4-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole | CHEMBL216214 | Glycoconjugate Benzene Sulfonamide 3e | methyl (2S,3S,4S,5R,6R)-3,4,5-tris(acetyloxy)-6-(4-{[(4-sulfamoylphenyl)carbonyloxy]methyl}-1H-1,2,3-triazol-1-yl)oxane-2-carboxylate
TypeSmall organic molecule
Emp. Form.C23H26N4O13S
Mol. Mass.598.537
SMILESCOC(=O)[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(COC(=O)c2ccc(cc2)S(N)(=O)=O)nn1
Structure
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