| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 14 |
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| Ligand | BDBM12941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_441220 (CHEMBL891444) |
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| Ki | 10.8±n/a nM |
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| Citation |  Wilkinson, BL; Bornaghi, LF; Houston, TA; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett17:987-92 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 14 |
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| Name: | Carbonic anhydrase 14 |
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| Synonyms: | CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37665.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human (cloned) isozyme. |
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| Residue: | 337 |
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| Sequence: | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
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| BDBM12941 |
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| n/a |
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| Name | BDBM12941 |
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| Synonyms: | 4-({[4-(Aminosulfonyl)benzoyl]oxy}methyl-1-(beta-D-maltosyl)-1H-1,2,3-triazole | CHEMBL217288 | Glycoconjugate Benzene Sulfonamide 3ff | {1-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]-1H-1,2,3-triazol-4-yl}methyl 4-sulfamoylbenzoate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N4O14S |
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| Mol. Mass. | 606.557 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)C(=O)OCc1cn(nn1)[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |
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| Structure | 
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