Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50209490 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_443548 (CHEMBL893805) |
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Ki | 13±n/a nM |
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Citation | Loriga, G; Ruiu, S; Manca, I; Murineddu, G; Dessi, C; Pani, L; Pinna, GA 3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]heptanes as novel potent dopamine uptake inhibitors. Bioorg Med Chem15:3748-55 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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BDBM50209490 |
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n/a |
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Name | BDBM50209490 |
Synonyms: | 3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-6-[(E)-3-thiophen-2-ylallyl]-3,6-diazabicyclo[3.1.1]heptane fumarate |
Type | Small organic molecule |
Emp. Form. | C27H28F2N2OS |
Mol. Mass. | 466.586 |
SMILES | Fc1ccc(cc1)C(OCCN1CC2CC(C1)N2C\C=C\c1cccs1)c1ccc(F)cc1 |w:13.13,15.16,TLB:10:11:17:14,18:17:11.12.16:14| |
Structure |
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