Reaction Details | |||
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Target | Bifunctional epoxide hydrolase 2 | ||
Ligand | BDBM50217458 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_444681 (CHEMBL894930) | ||
IC50 | 0.55±n/a nM | ||
Citation | Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem50:3825-40 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bifunctional epoxide hydrolase 2 | |||
Name: | Bifunctional epoxide hydrolase 2 | ||
Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
Type: | Enzyme | ||
Mol. Mass.: | 62613.07 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34913 | ||
Residue: | 555 | ||
Sequence: |
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BDBM50217458 | |||
n/a | |||
Name | BDBM50217458 | ||
Synonyms: | CHEMBL244192 | cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea | ||
Type | Small organic molecule | ||
Emp. Form. | C24H34N2O3 | ||
Mol. Mass. | 398.5384 | ||
SMILES | COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 |wU:10.13,7.6,TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17,16:17:20:24.23.22,(5.89,-12.26,;5.07,-10.96,;3.53,-11.02,;2.8,-12.38,;1.27,-12.43,;.45,-11.13,;-1.09,-11.18,;-1.81,-12.54,;-3.35,-12.6,;-4.07,-13.97,;-3.26,-15.26,;-1.71,-15.21,;-.99,-13.85,;-3.97,-16.62,;-5.51,-16.68,;-6.33,-15.38,;-6.23,-18.05,;-7.77,-18.11,;-8.78,-19.39,;-10.19,-18.82,;-11.69,-19.24,;-10.49,-17.97,;-10.5,-16.48,;-9.15,-16.01,;-10.19,-17.24,;-7.75,-16.58,;-9.17,-18.46,;1.17,-9.77,;2.7,-9.71,)| | ||
Structure |